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Postdoctoral Research Scientist - Genome Biologist | Biologist, Research Scientist in Science, Pha1

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Postdoctoral Research Scientist - Genome Biologist

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Location:
Coatham Mundeville
Description:

Applications are invited for a Postdoctoral Research Scientist to join the group of Conrad Nieduszynski at the Earlham Institute, based in Norwich, UK. Background: Single molecule analysis of Human DNA replication Complete, accurate genome replication is essential for life. Complete genome replication is achieved by initiating DNA replication at thousands of discrete sites. Both the characteristics of replication initiation sites and subsequent interruptions to replication have been implicated in human genetic and phenotypic variation (Saxena & Zou, 2022). The location and distribution of replication initiation sites across the human genome have been proposed to underlie genome instability and the biogenesis of tumorigenic translocations. This project will apply nanopore sequencing to identifies replication initiation sites across the human genome. In collaboration with the Kanemaki group (National Institute of Genetics, Japan) and Oxford Nanopore Technologies we will apply nanopore sequencing to characterise the dynamics of human genome replication on single molecules (Mülleret al. 2019). This will identify sites of DNA replication initiation and sequences that impede the replication fork. Induced protein degradation will be used to test factors involved in replication initiation and stable replication fork progression. Precise identification of sites of replication initiation and replication impediment is crucial since such sites have been implicated in the biogenesis of tumorigenic translocations. Saxena & Zou (2022). Hallmarks of DNA replication stress. Mol Cell 82, 2298–2314. Müller et al. (2019). Capturing the dynamics of genome replication on individual ultra-long nanopore sequence reads. Nat. Methods,16:429. The role: This post requires a cell biologist / genome biologist with experience of high throughput sequencing with an interest in using their expertise to study fundamental biological processes and the causes of genome instability. . Visit ListedBuy for more information.
Company:
John Innes Centre
Posted:
January 27 on ListedBuy
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